Daniele Simoneschi

Daniele was born in Rome, Italy, where he obtained a high school diploma for sciences from Liceo Scientifico Statale Farnesina and a degree in music from Conservatorio di Musica Santa Cecilia. In 2009, Daniele moved to the United States where he received a Chairman Award Scholarship from Manhattanville College, graduating valedictorian with a major in biochemistry and two minors: music and mathematics. Upon the completion of his undergraduate studies, Daniele joined the laboratory of Dr. Michele Pagano at the New York University Grossman School of Medicine, where he obtained his M.Phil. in Pathobiology and Translational Medicine, and a Ph.D. in Molecular Oncology and Tumour Immunology in 2021. As a graduate student, Daniele focused on the molecular and cellular mechanisms by which cullin-RING ubiquitin ligases (CRLs) regulate the execution of the cell-division cycle. Specifically, Daniele established that the tumor suppressor AMBRA1 acts as a CRL4 substrate receptor that dictates the specificity towards phosphorylated D-type cyclins during cell-cycle progression, and demonstrated that the deregulation of this pathway contributes to the pathogenesis of diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma in the United States and worldwide. To explore novel oncogenic pathways regulated by CRLs, Daniele then served as a Senior Research Coordinator in the laboratory of Dr. Michele Pagano, and was subsequently appointed to the position of faculty member in the Department of Biochemistry and Molecular Pharmacology at the New York University Grossman School of Medicine, where he currently serves as a Research Assistant Professor.